Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation
Lun Li, Rhonda Lightle, Bader Ali, Georgeio Sader, Robert Shenkar, Sean P. Polster, Douglas A. Marchuk, Jan-Karl Burkhardt, Issam A. Awad, Mark L. Kahn
Lun Li, Rhonda Lightle, Bader Ali, Georgeio Sader, Robert Shenkar, Sean P. Polster, Douglas A. Marchuk, Jan-Karl Burkhardt, Issam A. Awad, Mark L. Kahn
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Research Letter Neuroscience Vascular biology

Growth of PIK3CA-driven cerebral cavernous malformations does not require microbiome stimulation

Abstract

Authors

Lun Li, Rhonda Lightle, Bader Ali, Georgeio Sader, Robert Shenkar, Sean P. Polster, Douglas A. Marchuk, Jan-Karl Burkhardt, Issam A. Awad, Mark L. Kahn

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Figure 1

Antibiotic treatment does not prevent PIK3CA-driven CCM growth in the adult brain.

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Antibiotic treatment does not prevent PIK3CA-driven CCM growth in the ad...
(A) Adult Krit1fl/fl; iPik3caH1047R mice received antibiotics (ABX) before craniotomy and focal AAV-Cre injections. (B and C) qPCR quantification of bacterial 16S rRNA (B) and Bacteroidetes s24-7 rRNA (C). n = 5/group. (D) Representative CCM preogression. (E) Representative gross and microCT images. (F) Lesion volumes on POD 21. Control, n = 9; ABX, n = 10. **P < 0.01, ***P < 0.01, ****P < 0.0001. NS, no significant difference (P = 0.6620).