JCI Insight -- New Articles https://token.jci.org/current en-us 2026 The American Society for Clinical Investigation JCI Insight http://insight.jci.org/assets/common/jci-only-white-blue-bg.png http://insight.jci.org <![CDATA[Epigenomic profiling links IGF2 overexpression to anthracycline resistance in colorectal cancer organoids]]> https://token.jci.org/articles/view/195194 info:doi/10.1172/jci.insight.195194 The American Society for Clinical Investigation <![CDATA[Proteomic profiling of plasma extracellular vesicles reveals a therapeutically targetable liver-heart axis in cardiac transplantation]]> https://token.jci.org/articles/view/200422 info:doi/10.1172/jci.insight.200422 The American Society for Clinical Investigation <![CDATA[Constitutive YAP activation in distal nephron segments disrupts epithelial identity and nephron patterning]]> https://token.jci.org/articles/view/203999 info:doi/10.1172/jci.insight.203999 The American Society for Clinical Investigation <![CDATA[Renin cells orchestrate a neuro-endocrine microenvironment of the kidney arterial tree in health and disease]]> https://token.jci.org/articles/view/197709 info:doi/10.1172/jci.insight.197709 The American Society for Clinical Investigation <![CDATA[A validated, modifiable proteomic score from the EXSCEL trial predicts cardiovascular events in diabetes]]> https://token.jci.org/articles/view/204463 info:doi/10.1172/jci.insight.204463 The American Society for Clinical Investigation <![CDATA[Peptide-phosphorodiamidate morpholino oligomer therapy for dysferlinopathy induces pseudoexon skipping and restoration of functional protein]]> https://token.jci.org/articles/view/204742 info:doi/10.1172/jci.insight.204742 The American Society for Clinical Investigation <![CDATA[Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders]]> https://token.jci.org/articles/view/202947 info:doi/10.1172/jci.insight.202947 The American Society for Clinical Investigation <![CDATA[Aberrant mucin expression and keratinization distinguishing severe from mild asthma revealed by interpretable machine learning]]> https://token.jci.org/articles/view/202442 info:doi/10.1172/jci.insight.202442 The American Society for Clinical Investigation <![CDATA[CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis]]> https://token.jci.org/articles/view/196197 info:doi/10.1172/jci.insight.196197 The American Society for Clinical Investigation <![CDATA[A tailored in vivo CRISPR screen identifies BAP1 as a potent tumor suppressor of sarcoma]]> https://token.jci.org/articles/view/192686 info:doi/10.1172/jci.insight.192686 The American Society for Clinical Investigation <![CDATA[HDAC6 inhibition alleviates mitochondrial trafficking in models of Charcot-Marie-Tooth disease type 2A]]> https://token.jci.org/articles/view/200106 info:doi/10.1172/jci.insight.200106 The American Society for Clinical Investigation <![CDATA[A whole-blood cryopreservation method streamlines clinical sample collection for multimodal single-cell immune profiling in sepsis]]> https://token.jci.org/articles/view/204610 info:doi/10.1172/jci.insight.204610 The American Society for Clinical Investigation <![CDATA[Inherited salt retention is associated with increased IL-17 responses and autoimmunity.]]> https://token.jci.org/articles/view/206932 info:doi/10.1172/jci.insight.206932 The American Society for Clinical Investigation <![CDATA[A large animal model of heritable pulmonary arterial hypertension using BMPR2 gene–edited sheep]]> https://token.jci.org/articles/view/205583 info:doi/10.1172/jci.insight.205583 The American Society for Clinical Investigation <![CDATA[BCG vaccination elicits protection against M. tuberculosis infection mediated by two phases of T cell immunity]]> https://token.jci.org/articles/view/201000 info:doi/10.1172/jci.insight.201000 The American Society for Clinical Investigation <![CDATA[Innate immune sensor NOD2 promotes cartilage degradation and osteoarthritis progression by stabilizing TRAF6 in chondrocytes]]> https://token.jci.org/articles/view/196750 info:doi/10.1172/jci.insight.196750 The American Society for Clinical Investigation <![CDATA[Matrikines dictate the amplitude of inflammation in smoke-related Streptococcus pneumoniae pulmonary infection]]> https://token.jci.org/articles/view/203605 info:doi/10.1172/jci.insight.203605 The American Society for Clinical Investigation <![CDATA[TRANCE is a unique marker of chronic pancreatitis in children]]> https://token.jci.org/articles/view/198911 info:doi/10.1172/jci.insight.198911 The American Society for Clinical Investigation <![CDATA[Reduced dosage of Kmt2d modifies Tbx1 haploinsufficiency toward phenotypes of 22q11.2DS]]> https://token.jci.org/articles/view/206763 info:doi/10.1172/jci.insight.206763 The American Society for Clinical Investigation <![CDATA[Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates]]> https://token.jci.org/articles/view/195683 info:doi/10.1172/jci.insight.195683 The American Society for Clinical Investigation <![CDATA[Cellular and molecular dysregulation of the esophageal epithelium in systemic sclerosis]]> https://token.jci.org/articles/view/195322 info:doi/10.1172/jci.insight.195322 The American Society for Clinical Investigation <![CDATA[Mutation-resolved single-cell transcriptomics reveals enhanced β-amyloid clearance in TET2-mutant human monocytes]]> https://token.jci.org/articles/view/208804 info:doi/10.1172/jci.insight.208804 The American Society for Clinical Investigation <![CDATA[Microbiome-derived metabolites shape CD4+ T cell differentiation and immune aging in HIV-1 infection]]> https://token.jci.org/articles/view/204383 info:doi/10.1172/jci.insight.204383 The American Society for Clinical Investigation <![CDATA[De novo VPS16 missense variant causes infantile-onset dystonia with defective autophagic flux]]> https://token.jci.org/articles/view/207998 info:doi/10.1172/jci.insight.207998 The American Society for Clinical Investigation <![CDATA[ATF7 drives diabetic wound healing via NOTCH1 repression and N1ICD-dependent macrophage polarization control]]> https://token.jci.org/articles/view/201178 info:doi/10.1172/jci.insight.201178 The American Society for Clinical Investigation <![CDATA[Clonal hematopoiesis is associated with progression of idiopathic pulmonary fibrosis]]> https://token.jci.org/articles/view/198458 info:doi/10.1172/jci.insight.198458 The American Society for Clinical Investigation <![CDATA[SARS-CoV-2 infection produces an IL-33–dependent chronic eosinophilic pneumonia and muco-inflammatory airways disease in Scnn1b-Tg mice]]> https://token.jci.org/articles/view/203283 info:doi/10.1172/jci.insight.203283 The American Society for Clinical Investigation <![CDATA[The molecular similarity landscape of preclinical cancer models to patient tumors]]> https://token.jci.org/articles/view/206449 ) compared with patient-derived organoids (PDOs), which are equal in hierarchy to that of PDX-dervied organoids (PDXOs) > cell lines. We also quantified high molecular conservation (Pearson correlation coefficient = 0.96) across paired in vitro to in vivo platform (organoids to PDX) transitions. Furthermore, genomic analysis demonstrated that whole-exome sequencing (WES) outperforms RNA-seq in detecting DNA variants, and it identified a clonal complexity hierarchy (cell lines > PDXOs > PDXs > PDOs) reflecting the effect of passaging history on intratumor heterogeneity. Ultimately, this study delivers a comprehensive quantitative benchmark, establishing a population-level hierarchy of molecular similarity between preclinical models and primary tumors and providing a data-driven reference for model selection. These findings offer a data-driven framework for selecting models that balance biological representativeness with experimental practicality.]]> info:doi/10.1172/jci.insight.206449 The American Society for Clinical Investigation <![CDATA[USP10 mitigates Ang II–induced atrial remodeling and atrial fibrillation susceptibility by deubiquitinating NDUFS1]]> https://token.jci.org/articles/view/195761 info:doi/10.1172/jci.insight.195761 The American Society for Clinical Investigation <![CDATA[Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis]]> https://token.jci.org/articles/view/201114 info:doi/10.1172/jci.insight.201114 The American Society for Clinical Investigation <![CDATA[Granulocytic myeloid–derived suppressor cells sustain HIV reservoirs by inhibiting viral reactivation via arginase 1–mediated mechanisms]]> https://token.jci.org/articles/view/202628 info:doi/10.1172/jci.insight.202628 The American Society for Clinical Investigation