ResearchIn-Press PreviewNephrologyPublic Health
Open Access | 
10.1172/jci.insight.203039
Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts
Yintong Chen,1 Weiwei Xu,1 Jieli Yu,1 Pei Deng,1 Nianping Liu,2 Yinyin Li,1 Hui Zhou,1 Hong Zhou,1 Jianchuan Wang,3 Bo Zhao,4 Florian Winau,5 Fan Fan Hou,1 and Yu Hu1
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
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1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Xu, W. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Yu, J. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
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1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Liu, N. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Li, Y. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Zhou, H. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Zhou, H. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Wang, J. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Zhao, B. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Winau, F. in: PubMed | Google Scholar
1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
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Hou, F.
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1Division of Nephrology, Southern Medical University, Guangzhou, China
2Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
3School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China
4Molecular Cancer Research Center, Sun Yat-sen University, Guangzhou, China
5Department of Pediatrics, Harvard Medical School, Boston, United States of America
Find articles by Hu, Y. in: PubMed | Google Scholar
Published September 17, 2026 - More info
Copyright © 2026, Chen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
