ResearchIn-Press PreviewNeuroscienceOphthalmology
Open Access | 
10.1172/jci.insight.202223
Optic nerve regeneration requires the intracellular domain of LIFRα/CD118
Qian Jiang,1 Cong Wang,1 Yuerong Ren,1 Peiyun Duan,1 Ke Tian,1 Xiangwei Duan,1 Binghan Cai,1 Changzhong Xu,1 Ke Liu,1 Jian Li,2 Larry Benowitz,3 Ningli Wang,4 Bing Jiang,1 and Lili Xie1
1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
Find articles by Tian, K. in: PubMed | Google Scholar
1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
Find articles by Duan, X. in: PubMed | Google Scholar
1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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Benowitz, L.
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
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1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
Find articles by Jiang, B. in: PubMed | Google Scholar
1Department of Ophthalmology, Central South University, Changsha, China
2Division of Rheumatology, Harvard Medical School, Boston, United States of America
3Departments of Neurosurgery and Ophthalmology, Boston Children’s Hospital and Harvard Medical School, Boston, United States of America
4Department of Ophthalmology, Capital Medical University, Beijing, China
Find articles by Xie, L. in: PubMed | Google Scholar
Published September 1, 2026 - More info
Copyright © 2026, Jiang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
